Novartis Expands US Innovation Footprint with USD 23 Billion R&D Push, Including New San Diego Research Hub

09 February 2026 | Monday | News

AI-enabled facility will support end-to-end drug discovery and advance gene therapies, RNA medicines, and targeted protein degradation

  • New facility will enable endtoend discovery across key disease areas and technology platforms, joining existing global research sites including Cambridge, Massachusetts, and Basel, Switzerland
  • Approximately 466,000-square-foot site with AI-enabled discovery capabilities, expected to house about 1,000 employees
  • Part of a USD 23 billion US investment to expand R&D and advanced manufacturing to reach more patients

Novartis broke ground on a new, state-of-the-art global Biomedical Research center in San Diego, California, designed to provide world-class scientific infrastructure and drug-discovery capabilities to advance the company’s pipeline for patients.
  
Once operational in 2029, the approximately 466,000-square-foot facility is expected to house about 1,000 Novartis employees and integrate seamlessly with Novartis global research sites including Cambridge, Massachusetts, and Basel, Switzerland, enabling integrated discovery efforts across regions.
  
“This new research center will strengthen our scientific leadership and accelerate the discovery of transformative medicines for patients worldwide, while deepening our connectivity with biotech, academic and technology partners across the region,” said Fiona Marshall, President of Biomedical Research at Novartis. “Designed to power future drug discovery, with a focus on genetics and human biology in key therapeutic areas such as neuroscience and oncology, it will create a single Novartis research center within one of the world’s premier life sciences ecosystems—accelerating our pipeline from discovery to patients.”
  
Government leaders and community partners joined Novartis employees in San Diego to mark the start of construction at the groundbreaking ceremony.
  
“This investment by Novartis reinforces San Diego as a place where breakthrough science happens and where innovation translates into high-quality jobs and life-changing medicines,” said Todd Gloria, San Diego Mayor. “San Diego is a global leader in life sciences because we bring together world-class talent, cutting-edge research and a collaborative ecosystem that turns discovery into impact. We’re proud to welcome this new research center and to continue building an economy rooted in innovation and results.”
  
The new facility builds on more than 25 years of Novartis research and development in San Diego and will support end-to-end drug discovery across core disease areas, including neuroscience, global health, oncology and age-related diseases and regenerative medicine. It will also expand the company’s capabilities in next-generation technology platforms, such as gene and cell therapies, RNA-based therapies, biologics and targeted protein degradation, and will advance novel delivery systems that open new therapeutic possibilities.
  
“Rooted in a strong legacy of innovation in San Diego and California, we are inspired to shape the future—driving new breakthroughs that will transform care for millions of patients worldwide,” said Thierry Diagana, California Sites Head and Global Head of Global Health, Biomedical Research, Novartis.
  
With advanced artificial intelligence, data and computational capabilities embedded throughout, the facility will be a key part of the global Novartis Biomedical Research network, helping share insights, scale innovation, and deliver meaningful breakthroughs for patients worldwide.
  
The San Diego research facility is a key pillar of the company’s USD 23 billion US investment. This includes a new flagship manufacturing hub in North Carolina; the opening of a radioligand therapy (RLT) manufacturing facility in Carlsbad, California; investments to expand existing facilities in Indiana and New Jersey; and plans to build new RLT manufacturing facilities in Florida and Texas.
  

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